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Polyendocrine Metabolic Ovarian Syndrome (PMOS) is the updated medical name for the condition previously known as Polycystic Ovary Syndrome (PCOS). The new terminology reflects a growing understanding that this condition affects multiple hormonal and metabolic systems throughout the body, not just the ovaries. As the medical community adopts this updated terminology, you may see both PMOS and PCOS used interchangeably during the transition.
PMOS, formerly known as PCOS, affects almost 1 in 10 women and is the most common endocrine disorder among women of reproductive age.
Symptoms may include irregular periods, excess body or facial hair, acne, and difficulty maintaining a healthy weight. PMOS also may be associated with depression, difficulty getting pregnant, predisposition to type 2 diabetes, and other long-term health problems.
The UCSF Multidisciplinary PMOS Clinic offers an integrated approach to treating polyendocrine metabolic ovary syndrome. Our patients see a team of specialists in reproductive endocrinology, dermatology, nutrition, psychology, and genetics. We work together with each patient to create an individualized treatment plan.
The exact cause of PMOS (formerly known as PCOS) is not fully understood, but it is believed to result from a combination of genetic, hormonal, and environmental factors. Insulin resistance, excess androgen production, and inflammation may all contribute to the development of the condition. Because PMOS affects multiple body systems, symptoms and severity can vary from person to person.
Yes. Many people with PMOS are able to become pregnant, although the condition can make conception more difficult by interfering with regular ovulation. Lifestyle changes, medications to induce ovulation, and fertility treatments such as IVF can help many individuals successfully achieve pregnancy. A fertility specialist can recommend the most appropriate treatment based on your individual needs.
PMOS is diagnosed by evaluating your symptoms, medical history, and hormone levels while ruling out other conditions with similar symptoms. Your provider may also perform a physical exam, blood tests, and a pelvic ultrasound. Because not everyone with PMOS has ovarian cysts, diagnosis is based on established clinical criteria rather than ultrasound findings alone.
Research suggests that PMOS has a strong genetic component, meaning it can run in families. Having a close relative with PMOS may increase your risk of developing the condition, although genetics alone do not determine whether someone will be affected. Hormonal, metabolic, and environmental factors also play important roles.
Academic standards. Pioneering research. Personalized care. Start your journey at the UCSF Center for Reproductive Health, located in Northern California's San Francisco Bay Area.
Academic standards. Pioneering research. Personalized care. Start your journey at the UCSF Center for Reproductive Health, located in Northern California's San Francisco Bay Area.






