Hakan Cakmak, MD

Assistant Professor
Ob/Gyn, Reproductive Sciences
+1 415 353-3040

Dr. Hakan Cakmak received his medical degree from Istanbul University, Cerrahpasa School of Medicine, Turkey. He completed his residency in Obstetrics and Gynecology at Yale University. He subsequently received his fellowship training in Reproductive Endocrinology and Infertility at University of California, San Francisco. Dr. Cakmak is board certified in Obstetrics and Gynecology, and is a member of the American Society for Reproductive Medicine and Society of Reproductive Endocrinology and Infertility.

Dr. Cakmak has special interest and clinical expertise in assisted reproduction, fertility preservation, endometriosis, pelvic pain and minimally invasive surgery including laparoscopic/hysteroscopic surgery. He has over 40 publications in leading scientific journals in the fields of infertility, assisted reproduction, fertility preservation, assessment of egg quality, endometriosis and implantation. His current research is focused on the investigation of the regulation of gene expression during egg and early embryo development, and the prevention of toxic effects of cancer treatments on the ovary.

Dr. Cakmak is the recipient of multiple awards for clinical excellence and research including: the American Society for Reproductive Medicine Fertility Preservation Special Interest Group’s Prize Paper Award, Yale University John J. Meehan–Clifford R. Miller Award for academic excellence, Yale University “Resident of Excellence Award” for research, and the The Society of Laparoendoscopic Surgeons’ Outstanding Laparoendoscopic Resident Surgeon Award. In addition, his work on infertility has received two President’s Presenter Awards from the Society for Gynecologic Investigation.

“I feel honored to be part of a couple’s or individual’s journey into parenthood. My goals are to guide my patients in their challenging journey by delivering the most compassionate and individualized care, and to provide the best chance of success by utilizing the latest medical knowledge and the most advanced technologies.”
Publications: 

Response to ovarian stimulation is not impacted by a breast cancer diagnosis.

Human reproduction (Oxford, England)

Quinn MM, Cakmak H, Letourneau JM, Cedars MI, Rosen MP

p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival.

Reproductive sciences (Thousand Oaks, Calif.)

Cakmak H, Seval-Celik Y, Arlier S, Guzeloglu-Kayisli O, Schatz F, Arici A, Kayisli UA

Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells.

Proceedings of the National Academy of Sciences of the United States of America

Cakmak H, Franciosi F, Zamah AM, Cedars MI, Conti M

Random-start ovarian stimulation in patients with cancer.

Current opinion in obstetrics & gynecology

Cakmak H, Rosen MP

Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.

Nature cell biology

Chen J, Torcia S, Xie F, Lin CJ, Cakmak H, Franciosi F, Horner K, Onodera C, Song JS, Cedars MI, Ramalho-Santos M, Conti M

Ovarian stimulation in cancer patients.

Fertility and sterility

Cakmak H, Rosen MP

Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle.

Journal of assisted reproduction and genetics

Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF

Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.

Reproductive sciences (Thousand Oaks, Calif.)

Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A

Uterine dehiscence in early second trimester.

Obstetrics and gynecology

Zuckerwise LC, Cakmak H, Sfakianaki AK

Implantation failure: molecular mechanisms and clinical treatment.

Human reproduction update

Cakmak H, Taylor HS

Differential regulation of Akt phosphorylation in endometriosis.

Reproductive biomedicine online

Cinar O, Seval Y, Uz YH, Cakmak H, Ulukus M, Kayisli UA, Arici A

Immune-endocrine interactions in endometriosis.

Frontiers in bioscience (Elite edition)

Cakmak H, Guzeloglu-Kayisli O, Kayisli UA, Arici A

ABO and Rh blood groups distribution in patients with endometriosis.

Archives of gynecology and obstetrics

Matalliotakis I, Cakmak H, Goumenou A, Sifakis S, Ziogos E, Arici A

Endometriosis related to family history of malignancies in the Yale series.

Surgical oncology

Matalliotakis IM, Cakmak H, Krasonikolakis GD, Dermitzaki D, Fragouli Y, Vlastos G, Arici A

Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis.

The Journal of clinical endocrinology and metabolism

Murk W, Atabekoglu CS, Cakmak H, Heper A, Ensari A, Kayisli UA, Arici A

Impact of body mass index on IVF and ICSI outcome: a retrospective study.

Reproductive biomedicine online

Matalliotakis I, Cakmak H, Sakkas D, Mahutte N, Koumantakis G, Arici A

Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro.

Histochemistry and cell biology

Kizilay G, Cakmak H, Yen CF, Atabekoglu C, Arici A, Kayisli UA

The familial risk of breast cancer in women with endometriosis from Yale series.

Surgical oncology

Matalliotakis IM, Cakmak H, Mahutte N, Goumenou AG, Koumantakis G, Arici A

Familial aggregation of endometriosis in the Yale Series.

Archives of gynecology and obstetrics

Matalliotakis IM, Arici A, Cakmak H, Goumenou AG, Koumantakis G, Mahutte NG

Increased rate of endometriosis and spontaneous abortion in an in vitro fertilization program: no correlation with epidemiological factors.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Matalliotakis I, Cakmak H, Dermitzaki D, Zervoudis S, Goumenou A, Fragouli Y

Arguments for a left lateral predisposition of endometrioma.

Fertility and sterility

Matalliotakis IM, Cakmak H, Koumantakis EE, Margariti A, Neonaki M, Goumenou AG

Epidemiological characteristics in women with and without endometriosis in the Yale series.

Archives of gynecology and obstetrics

Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A

Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression.

The Journal of clinical endocrinology and metabolism

Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A

The role of endometrium in endometriosis.

Journal of the Society for Gynecologic Investigation

Ulukus M, Cakmak H, Arici A

Increased IL-18 levels in seminal plasma of infertile men with genital tract infections.

American journal of reproductive immunology (New York, N.Y. : 1989)

Matalliotakis IM, Cakmak H, Fragouli Y, Kourtis A, Arici A, Huszar G

Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium.

The Journal of clinical endocrinology and metabolism

Seval Y, Cakmak H, Kayisli UA, Arici A

Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window.

Human reproduction (Oxford, England)

Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A

Inhibition of chemokines prevents intraperitoneal adhesions in mice.

Human reproduction (Oxford, England)

Berkkanoglu M, Zhang L, Ulukus M, Cakmak H, Kayisli UA, Kursun S, Arici A

Progestin suppresses thrombin- and interleukin-1beta-induced interleukin-11 production in term decidual cells: implications for preterm delivery.

The Journal of clinical endocrinology and metabolism

Cakmak H, Schatz F, Huang ST, Buchwalder L, Rahman M, Arici A, Lockwood CJ