Mitchell Rosen, MD

Assoc Prof In Residence
Ob/Gyn, Reproductive Sciences
+1 415 885-7870

Dr. Mitchell Rosen is a reproductive endocrinology and fertility expert at the UCSF Center for Reproductive Health. He also is director of the UCSF Fertillity Preservation Center, which helps patients with cancer preserve their ability to have children, despite aggressive cancer treatment.

Rosen earned a medical degree at Saint Louis University and completed residency training in obstetrics and gynecology at the University of Texas Medical Branch in Galveston, Texas. During medical and residency training, he was named the best resident twice and received the Ortho-McNeil Best Resident Teacher Award in 2002. Rosen completed fellowship training in reproductive endocrinology and infertility at UCSF. He was trained in the UCSF embryology laboratory to qualify as a high complexity lab director (HCLD). In addition to caring for patients, he is an assistant professor of medicine at UCSF and teaches medical students, residents and fellows.

Dr. Rosen on his research: My research focuses on Reproductive Endocrinology and Infertility, oogenesis (folliculogenesis) and early reproductive failure. During my fellowship I explored a basic research interest in a candidate gene (DAZ-L) involved in gametogenesis, and determined that this gene may be involved in the age at ovarian failure and spermatogenesis. I am actively involved in studies to better understand the impact of exogenous stimulation on in vivo and subsequent in vitro oocyte development and maturation. Of particular interest is understanding ways to optimize controlled ovarian hyperstimulation to improve pregnancy outcomes during assisted reproduction. I have recently received funding to develop a randomized trial evaluating concomitant FSH with hCG for ovulation trigger. During a spontaneous ovulatory surge, there is a rise in both FSH and LH. While hCG has been substituted for the LH surge, no studies have addressed the role of FSH on the developing oocyte during the final steps of nuclear and cytoplasmic maturation. This prospective study will compare ovarian stimulation and follicular development, along with oocyte maturation, developmental competence, and quality between those participants receiving hCG alone or combined FSH/hCG. In addition, the intrafollicular hormonal milieu, embryo quality, and pregnancy rates will be compared between the two treatment groups.

I am also involved in several other studies, which focus on optimizing embryo selection, leading to single embryo transfer, and thereby decreasing health risks to women and their children. We have established a protocol utilizing proton magnetic spectroscopy and HPLC proteomics to compare embryos with and without known implantation. Additionally, I am a member of a research team addressing the role of methyl-tetrahydrafolate reductase in ovarian stimulation and IVF outcomes, and the effect CMV in semen has on fertilization and embryo quality. Ultimately, my goal is to promote a team effort between clinicians, basic scientists, and embryologists in order to better study folliculogenesis and apply this knowledge to understanding the process of ovarian aging and the impact of exogenous medications on follicle development.

"There are many reasons for having children. The unfulfilled desire for childbearing can be devastating. My goal is to optimize care for the infertile couple so that achieving a pregnancy becomes a reality."
Publications: 

Erratum to: Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy.

Breast cancer research and treatment

Chien AJ, Chambers J, Mcauley F, Kaplan T, Letourneau J, Hwang J, Kim MO, Melisko ME, Rugo HS, Esserman LJ, Rosen MP

Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy.

Breast cancer research and treatment

Chien AJ, Chambers J, Mcauley F, Kaplan T, Letourneau J, Hwang J, Kim MO, Melisko ME, Rugo HS, Esserman LJ, Rosen MP

ASRM standard embryo transfer protocol template: a committee opinion.

Fertility and sterility

Penzias A, Bendikson K, Butts S, Coutifaris C, Falcone T, Fossum G, Gitlin S, Gracia C, Hansen K, Mersereau J, Odem R, Rebar R, Reindollar R, Rosen M, Sandlow J, Vernon M

Response to ovarian stimulation is not impacted by a breast cancer diagnosis.

Human reproduction (Oxford, England)

Quinn MM, Cakmak H, Letourneau JM, Cedars MI, Rosen MP

Regret around fertility choices is decreased with pre-treatment counseling in gynecologic cancer patients.

Journal of cancer survivorship : research and practice

Chan JL, Letourneau J, Salem W, Cil AP, Chan SW, Chen LM, Rosen MP

The role of in-depth reproductive health counseling in addressing reproductive health concerns in female survivors of nongynecologic cancers.

Journal of psychosocial oncology

Shah MS, Letourneau JM, Niemasik EE, Bleil M, McCulloch CE, Rosen MP

Regimen of ovarian stimulation affects oocyte and therefore embryo quality.

Fertility and sterility

Bosch E, Labarta E, Kolibianakis E, Rosen M, Meldrum D

Impact of pituitary suppression on antral follicle count and oocyte recovery after ovarian stimulation.

Fertility and sterility

Tran ND, Aghajanova L, Kao CN, Cedars MI, Rosen MP

Uterine didelphys associated with obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome.

Radiology case reports

Han B, Herndon CN, Rosen MP, Wang ZJ, Daldrup-Link H

Recruitment strategies in two reproductive medicine network infertility trials.

Contemporary clinical trials

Usadi RS, Diamond MP, Legro RS, Schlaff WD, Hansen KR, Casson P, Christman G, Wright Bates G, Baker V, Seungdamrong A, Rosen MP, Lucidi S, Thomas T, Huang H, Santoro N, Eisenberg E, Zhang H, Alvero R

Sexual satisfaction and quality of life in survivors of localized cervical and ovarian cancers following fertility-sparing surgery.

Gynecologic oncology

Chan JL, Letourneau J, Salem W, Cil AP, Chan SW, Chen LM, Rosen MP

Association of tamoxifen use and ovarian function in patients with invasive or pre-invasive breast cancer.

Breast cancer research and treatment

Chien AJ, Duralde E, Hwang R, Tsung K, Kao CN, Rugo HS, Melisko ME, Esserman LJ, Munster PN, Cedars M, Kerlikowske K, McCulloch CE, Rosen MP

Fertility Sparing Surgery for Localized Ovarian Cancers Maintains an Ability to Conceive, but is Associated With Diminished Reproductive Potential.

Journal of surgical oncology

Letourneau J, Chan J, Salem W, Chan SW, Shah M, Ebbel E, McCulloch C, Chen LM, Cedars M, Rosen M

Random-start ovarian stimulation in patients with cancer.

Current opinion in obstetrics & gynecology

Cakmak H, Rosen MP

Testicular niche required for human spermatogonial stem cell expansion.

Stem cells translational medicine

Smith JF, Yango P, Altman E, Choudhry S, Poelzl A, Zamah AM, Rosen M, Klatsky PC, Tran ND

Does accelerated reproductive aging underlie premenopausal risk for cardiovascular disease?

Menopause (New York, N.Y.)

Bleil ME, Gregorich SE, McConnell D, Rosen MP, Cedars MI

Accelerating ovarian age: cancer treatment in the premenopausal woman.

Seminars in reproductive medicine

Letourneau J, Chan SW, Rosen MP

Disruptions in ovarian function are related to depression and cardiometabolic risk during premenopause.

Menopause (New York, N.Y.)

Bleil ME, Bromberger JT, Latham MD, Adler NE, Pasch LA, Gregorich SE, Rosen MP, Cedars MI

Ovarian stimulation in cancer patients.

Fertility and sterility

Cakmak H, Rosen MP

Depressive symptomatology, psychological stress, and ovarian reserve: a role for psychological factors in ovarian aging?

Menopause (New York, N.Y.)

Bleil ME, Adler NE, Pasch LA, Sternfeld B, Gregorich SE, Rosen MP, Cedars MI

Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle.

Journal of assisted reproduction and genetics

Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF

Psychological stress and reproductive aging among pre-menopausal women.

Human reproduction (Oxford, England)

Bleil ME, Adler NE, Pasch LA, Sternfeld B, Gregorich SE, Rosen MP, Cedars MI

Patient perceptions of reproductive health counseling at the time of cancer diagnosis: a qualitative study of female California cancer survivors.

Journal of cancer survivorship : research and practice

Niemasik EE, Letourneau J, Dohan D, Katz A, Melisko M, Rugo H, Rosen M

Genetic markers of ovarian follicle number and menopause in women of multiple ethnicities.

Human genetics

Schuh-Huerta SM, Johnson NA, Rosen MP, Sternfeld B, Cedars MI, Reijo Pera RA

Can FSH co-trigger prevent OHSS?

Fertility and sterility

Rosen MP, Meldrum DR

A characterization of the relationship of ovarian reserve markers with age.

Fertility and sterility

Rosen MP, Johnstone E, McCulloch CE, Schuh-Huerta SM, Sternfeld B, Reijo-Pera RA, Cedars MI

Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.

Human reproduction (Oxford, England)

Schuh-Huerta SM, Johnson NA, Rosen MP, Sternfeld B, Cedars MI, Reijo Pera RA

Will imatinib compromise reproductive capacity?

The oncologist

Zamah AM, Mauro MJ, Druker BJ, Oktay K, Egorin MJ, Cedars MI, Rosen MP

The role of anti-müllerian hormone (AMH) in assessing ovarian reserve.

The Journal of clinical endocrinology and metabolism

Tran ND, Cedars MI, Rosen MP

Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer.

Cancer

Letourneau JM, Ebbel EE, Katz PP, Katz A, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP

Acute ovarian failure underestimates age-specific reproductive impairment for young women undergoing chemotherapy for cancer.

Cancer

Letourneau JM, Ebbel EE, Katz PP, Oktay KH, McCulloch CE, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP

Ethnic variation in estradiol metabolism in reproductive age Asian and white women treated with transdermal estradiol.

Fertility and sterility

Huddleston HG, Rosen MP, Gibson M, Cedars MI, Fujimoto VY

Reproductive capacity in iron overloaded women with thalassemia major.

Blood

Singer ST, Vichinsky EP, Gildengorin G, van Disseldorp J, Rosen M, Cedars MI

A lower antral follicle count is associated with infertility.

Fertility and sterility

Rosen MP, Johnstone E, Addauan-Andersen C, Cedars MI

Barriers and opportunities for early detection of breast cancer in Gaza women.

Breast (Edinburgh, Scotland)

Shaheen R, Slanetz PJ, Raza S, Rosen MP

A changing perspective: improving access to fertility preservation.

Nature reviews. Clinical oncology

Letourneau JM, Melisko ME, Cedars MI, Rosen MP

Human oocyte maturation is dependent on LH-stimulated accumulation of the epidermal growth factor-like growth factor, amphiregulin.

Human reproduction (Oxford, England)

Zamah AM, Hsieh M, Chen J, Vigne JL, Rosen MP, Cedars MI, Conti M

The polycystic ovary post-rotterdam: a common, age-dependent finding in ovulatory women without metabolic significance.

The Journal of clinical endocrinology and metabolism

Johnstone EB, Rosen MP, Neril R, Trevithick D, Sternfeld B, Murphy R, Addauan-Andersen C, McConnell D, Pera RR, Cedars MI

The arcuate uterine anomaly: a critical appraisal of its diagnostic and clinical relevance.

Obstetrical & gynecological survey

Mucowski SJ, Herndon CN, Rosen MP

Antral follicle count: absence of significant midlife decline.

Fertility and sterility

Rosen MP, Sternfeld B, Schuh-Huerta SM, Reijo Pera RA, McCulloch CE, Cedars MI

Is antral follicle count a genetic trait?

Menopause (New York, N.Y.)

Rosen MP, Johnstone EB, Gillham SJ, Modan AE, Lipshutz AK, Reijo-Pera R, Cedars MI

Tubo-ovarian abscess management options for women who desire fertility.

Obstetrical & gynecological survey

Rosen M, Breitkopf D, Waud K

Follicular fluid steroid hormone levels are associated with fertilization outcome after intracytoplasmic sperm injection.

Fertility and sterility

Lamb JD, Zamah AM, Shen S, McCulloch C, Cedars MI, Rosen MP

Fertilization rate is an independent predictor of implantation rate.

Fertility and sterility

Rosen MP, Shen S, Rinaudo PF, Huddleston HG, McCulloch CE, Cedars MI

The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery.

Reproductive biology and endocrinology : RB&E

Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo PF, Lamb JD, Cedars MI

A quantitative assessment of follicle size on oocyte developmental competence.

Fertility and sterility

Rosen MP, Shen S, Dobson AT, Rinaudo PF, McCulloch CE, Cedars MI

Prevalence of celiac disease in a cohort of women with unexplained infertility.

Fertility and sterility

Jackson JE, Rosen M, McLean T, Moro J, Croughan M, Cedars MI

Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity.

Fertility and sterility

Rosen MP, Shen S, McCulloch CE, Rinaudo PF, Cedars MI, Dobson AT

Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF.

Human reproduction (Oxford, England)

Dobson AT, Davis RM, Rosen MP, Shen S, Rinaudo PF, Chan J, Cedars MI

Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men.

Reproductive biology and endocrinology : RB&E

Tung JY, Rosen MP, Nelson LM, Turek PJ, Witte JS, Cramer DW, Cedars MI, Reijo-Pera RA

Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline.

American journal of perinatology

Pacheco LD, Rosen MP, Gei AF, Saade GR, Hankins GD

Day 2 transfer improves pregnancy outcome in in vitro fertilization cycles with few available embryos.

Fertility and sterility

Shen S, Rosen MP, Dobson AT, Fujimoto VY, McCulloch CE, Cedars MI

Triploidy formation after intracytoplasmic sperm injection may be a surrogate marker for implantation.

Fertility and sterility

Rosen MP, Shen S, Dobson AT, Fujimoto VY, McCulloch CE, Cedars MI

Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women.

Human genetics

Tung JY, Rosen MP, Nelson LM, Turek PJ, Witte JS, Cramer DW, Cedars MI, Pera RA

Subfertility and gastrointestinal disease: 'unexplained' is often undiagnosed.

Obstetrical & gynecological survey

Bradley RJ, Rosen MP

A randomized controlled trial of second- versus third-generation oral contraceptives in the treatment of acne vulgaris.

American journal of obstetrics and gynecology

Rosen MP, Breitkopf DM, Nagamani M

Utilization of outpatient diagnostic imaging. Does the physician's gender play a role?

Journal of general internal medicine

Rosen MP, Davis RB, Lesky LG

Valvectomy with use of a percutaneous directional atherectomy catheter in failing in situ saphenous vein grafts.

Journal of vascular and interventional radiology : JVIR

Weintraub JL, Sheiman RG, Rosen MP, Porter DH, Kim D